PART 11 of the series in
"The weight of our nation:
A study conducted in 2012 “(Common variants of FTO are associated with childhood obesity in a cross-sectional study of 3,126 urban Indian children.)” States the association of FTO variants with obesity, this study was performed on 3,126 Indian children (aged 11-17 years) including 2,230 normal-weight and 896 over-weight/obese children. This study indicates that the FTO gene factor is more prominent to affect children rather than adults.
There is a lot of research being done on obesity and its causes, however we normally look upon factors such as excess energy intake, reduced physical activity or lifestyles, there is another factor emerging as a major component in the rise of obesity. Genetics, Genetic variants play a key role in one’s body weight. It has emerged that there are particular variants associated to obesity and overweight. One such gene is FTO, also known as alpha-ketoglutarate-dependent dioxygenase FTO is an enzyme that in humans is encoded by the FTO gene located on chromosome 16.
People have two copies of the FTO gene - one from each parent - and each copy comes in a high and a low-risk form. Those with two-high risk copies of the FTO gene are thought to be 70% more likely to become obese than those with low-risk genes. This mechanism works by affecting the ghrelin hormone.
Another hormone AMD1 is a genetic variant associated with childhood obesity.
A study conducted in 2012 (Genetic variant of AMD1 is associated with obesity in urban Indian children.) this study indicates that there is an association of AMD1 (adenosylmethionine decarboxylase 1) variant with obesity and plasma leptin levels in children.
# Common variants of FTO are associated with childhood obesity in a cross-sectional study of 3,126 urban Indian children.
Dwivedi OP, Tabassum R, Chauhan G, Ghosh S, Marwaha RK, Tandon N, Bharadwaj D. Source: Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, India. http://www.ncbi.nlm.nih.gov/pubmed/23091647
# BMC Public Health. 2012 Oct 17;12:881. doi: 10.1186/1471-2458-12-881.
Association of breakfast intake with obesity, dietary and physical activity behavior among urban school-aged adolescents in Delhi, India: results of a cross-sectional study.
Arora M, Nazar GP, Gupta VK, Perry CL, Reddy KS, Stigler MH. Source: Health Related Information Dissemination Amongst Youth, Safdarjung Development Area, New Delhi 110016, India. firstname.lastname@example.org
# J Prev Med Public Health. 2013 Jul;46(4):192-200. doi: 10.3961/jpmph.2013.46.4.192. Epub 2013 Jul 31. Behavioural Determinants for Obesity: A Cross-sectional Study Among Urban Adolescents in India. Rani MA, Sathiyasekaran BW. Source: Department of Community Medicine, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Chennai, India.
# Bariatric surgery for obese children and adolescents: a review of the moral challenges
# PLoS One. 2012;7(4):e33162. doi: 10.1371/journal.pone.0033162. Epub 2012 Apr 9. Genetic variant of AMD1 is associated with obesity in urban Indian children.